The Associate Director, External Manufacturing will serve as Arrowhead’s primary technical and operational owner for a focused portfolio of 1–3 strategic Contract Development and Manufacturing Organizations (CDMOs) supporting the manufacture of siRNA-based therapeutics. This individual will be accountable for end-to-end CDMO relationship management, technology transfer, GMP supply, and lifecycle performance for drug substance (oligonucleotide synthesis and conjugation), targeted delivery components (e.g., GalNAc and other ligand systems), and/or drug product manufacturing operations.
Operating as the single point of accountability for assigned CDMO partners, this leader will work seamlessly across Process Development, Analytical Development, Quality, Regulatory, Supply Chain, Program Management, and Clinical Operations to ensure robust, compliant, predictable, and cost-effective supply of clinical and commercial product. The successful candidate is, above all, a highly effective cross-functional leader — someone who builds trust quickly, drives alignment among diverse stakeholders, and converts technical complexity into clear decisions and forward momentum.
This role plays a critical part in scaling Arrowhead’s platform-enabled RNAi candidates from development through late-stage clinical and commercial readiness, while supporting global regulatory filings and inspection readiness.
This position is approved at the Associate Director level. Candidates with significantly greater depth of relevant experience, demonstrated leadership of complex external manufacturing programs, and a track record of successfully managing late-stage or commercial CDMO partnerships may be considered at the Director level. Final leveling will be based on experience and qualifications.
This role is based in onsite with an expectation to be in the office five days a week.