FinalDose’s platform requires delivery solutions tailored to each therapeutic indication. You will lead delivery engineering across multiple administration routes, optimizing lipid nanoparticle formulations for tissue-specific targeting and therapeutic efficacy. Your work will bridge in vitro formulation development with in vivo validation and ultimately support technology transfer for GMP manufacturing. This is a critical role linking our construct engineering with clinical-stage drug products.
Responsibilities
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Lead LNP delivery engineering across multiple administration routes, including local, systemic, and inhaled formulations
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Develop and optimize LNP formulations with full physicochemical characterization (DLS, encapsulation efficiency, zeta potential)
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Perform in vitro delivery optimization and hand off validated formulations to the in vivo team for animal studies
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Support CMO/CDMO selection and technology transfer for GMP-grade manufacturing
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Collaborate with biology teams to evaluate delivery efficiency using functional readouts (editing efficiency, reporter assays) in cell lines and primary cells
Required
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Ph.D. in pharmaceutical sciences, drug delivery, biomedical engineering, or chemical engineering
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3–5+ years of hands-on experience with lipid nanoparticle formulation
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Demonstrated expertise in at least two of the following: mRNA-LNP encapsulation and delivery, tissue-targeted delivery (SORT technology or ionizable lipid screening), inhaled or pulmonary drug delivery
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Experience with microfluidic mixing and formulation scale-up
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In vitro delivery characterization in cell lines and primary cells
Preferred
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Experience with intravesical or local drug delivery
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CMC or technology transfer experience with a CDMO
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Air-liquid interface (ALI) culture and aerosol delivery expertise
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Awareness of GMP manufacturing processes and requirements