As an integral member of our dynamic team, you will:
• Serve as lead/project pathologist for multiple complex development programs and provide independent pathology strategy from discovery and candidate selection through regulatory milestones and later-stage development, as needed.
• Provide expert veterinary, clinical, technical, and scientific input for studies, including necropsy, clinical pathology and histopathology interpretation, pathology peer review, and integrated assessment of study findings.
• Partner closely with toxicologists, study operations professionals, translational scientists, pharmacologists, clinicians, and regulatory colleagues to design fit-for-purpose GLP and non-GLP safety programs that answer key development questions efficiently.
• Rapidly synthesize complex or incomplete datasets, leverage the external literature, and develop clear best-evidence positions that support risk assessment, dose selection, study design, and program decisions.
• Anticipate potential target-, modality-, or mechanism-related safety issues and design or lead investigative and mechanistic studies to resolve uncertainty and inform development strategy.
• Contribute to and, where appropriate, lead the development of safety biomarkers, diagnostics, digital/computational pathology approaches, and new approach methodologies (NAMs) that strengthen translation and decision making.
• Identify opportunities to refine study design and reduce or replace animal use where scientifically appropriate, while maintaining robust safety assessment and regulatory readiness.
• Author or critically review regulatory documents and presentations; represent Translational Safety and Genentech/Roche in interactions with health authorities and support programs using novel, accelerated, or otherwise nontraditional regulatory strategies.
• Provide proactive, high-impact scientific and strategic pathology leadership beyond assigned programs, including leadership of cross-functional initiatives, therapeutic-area or expert working groups, and functional capability-building efforts.
• Mentor pathologists and other scientists, promote rigorous and pragmatic scientific decision making, and contribute to an inclusive, collaborative, high-performing team culture.
• Advance the external scientific standing of Genentech/Roche through high-quality publications, presentations, scientific collaborations, and participation in relevant professional or industry forums.