The Department occupies 28,700 square feet of laboratory and office space. Investigators have dedicated shared resources for large‑scale data analysis and functional validation, including priority access to cloud computing, a local high‑performance computing facility housed in a state‑of‑the‑art data center, a genomics laboratory for developing new omics technologies and assays, a wet lab supporting dry‑lab faculty, and an software engineering team for high‑throughput analysis and pipeline automation. The Department is key in multiple completed and ongoing institutional projects, including Pediatric Cancer Genome Project (PCGP), St. Jude Cloud, PedDep Accelerator, Real Time Clinical Genomics, iTARGETS, and COMET. The research environment at St. Jude is highly collaborative, with opportunities across basic and clinical departments and access to institution‑wide core facilities led by PhD‑level scientists.