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LI
Lilly

Advisor – Engineering – Drug Substance

Salary$129k – $209k
LocationUS, Indianapolis IN
Work modeon-site
Typefull-time
SenioritySenior
Experience7+ yrs
Company size10,000+ people
First seenOct 8, 2026 · 3d ago
Verified live1d ago
At a glanceSummarised by Seekless from the posting.
Must have13
PhD in Chemical Engineering
MSc in Chemical Engineering +7 years of experience in chemical/pharmaceutical process development
BSc in Chemical Engineering +10 years of experience in chemical/pharmaceutical process development
Apply engineering fundamentals to design and optimize chemical processes for small molecules, oligonucleotides, and synthetic peptides
Design and execute lab experiments using knowledge of reaction kinetics, heat/mass transfer, thermodynamics, fluid dynamics, and process modeling
Develop proficiency across unit operations including crystallization, filtration, drying, milling, and batch/continuous chemistry
Serve on integrated commercialization teams to develop, test, and oversee process execution
Operate with full compliance within a regulated industry
Collaborate cross-functionally with analytical, formulation, quality, regulatory, and environmental/safety teams
Oversee scale-up and technology transfer to manufacturing sites
Maintain a continuous learning mindset
Provide mentorship to junior scientists and engineers
Foster an inclusive, collaborative environment
Nice to have8
Experience with design, development, and optimization of synthetic process manufacturing unit operations
Experience with modeling and simulation tools, data analytics and predictive analytics
Experience in batch and continuous unit operations
Excellent oral communication and documentation skills
Demonstrate ability to effectively collaborate with multidisciplinary teams
Demonstrate leadership behaviors including ability to accept challenges, seek opportunities to remove barriers, influence without authority, and lead in areas of uncertainty
Demonstrate exemplary teamwork/interpersonal skills
Demonstrate problem solving, attention to detail and result oriented behaviors in a fast-paced environment
Eligibility3
Travel: 0 to 10%
Lilly is proud to be an EEO Employer and does not discriminate
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce
Skills
Python
React
AWS
PostgreSQL
Benefits
Health insurance
401(k)
Pension
Dental insurance
Vision insurance
Life insurance
Bonus
About the company
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
Lilly’s Synthetic Molecule Design and Development (SMDD) is involved in key activities for the development of active pharmaceutical ingredients and formulated drug products from pre-clinical phases through commercialization of drug substances and drug products for small molecules, synthetic oligonucleotides, and synthetic peptides. Our scientists develop key technical and business solutions across the portfolio using their deep technical expertise to speed up testing of the clinical hypothesis and overall drug development. SMDD tackles this diversity of responsibilities by recognizing that an even greater diversity of talents and cultures is necessary to deliver the next generation of life changing medicines to patients.
About the role
SMDD is seeking outstanding engineering candidates to work within the process design and development team. The position presents an opportunity to work side by side with chemists, analytical chemists, formulation scientists and other engineers to develop new technical solutions to accelerate our exciting portfolio. Candidates must demonstrate a history of strong technical depth, scientific leadership, and a willingness to promote a collaborative, team-based approach to problem solving.
Responsibilities:
•
Apply engineering fundamentals to design and optimize chemical processes for small molecules, oligonucleotides, and synthetic peptides, ensuring robust, scalable processes that reliably supply clinical trial materials.
•
Design and execute lab experiments using knowledge of reaction kinetics, heat/mass transfer, thermodynamics, fluid dynamics, and process modeling to support error-free scale-up.
•
Develop proficiency across a broad range of unit operations — including crystallization, filtration, drying, milling, and batch/continuous chemistry — to assemble complete synthetic manufacturing processes.
•
Serve on integrated commercialization teams to collaboratively develop, test, and oversee process execution from lab scale through manufacturing facilities.
•
Operate with full compliance within a regulated industry, adhering to applicable regulations, guidelines, SOPs, and safety procedures governing drug research and development.
•
Collaborate cross-functionally with analytical, formulation, quality, regulatory, and environmental/safety teams to ensure comprehensive process development and compliance.
•
Oversee scale-up and technology transfer to internal and external manufacturing sites through team meetings, site visits, and ongoing process monitoring.
•
Maintain a continuous learning mindset by engaging with relevant literature, professional organizations, and the broader scientific community through publications and conference presentations.
•
With experience, provide mentorship to junior scientists and engineers while driving documentation and broad sharing of new technologies, methodologies, and process control strategies.
•
Foster an inclusive, collaborative environment that encourages diverse perspectives to deliver innovative solutions to unmet technical challenges.
Education Requirements:
•
PhD in Chemical Engineering
•
MSc in Chemical Engineering +7 years of experience in chemical/pharmaceutical process development
•
BSc in Chemical Engineering +10 years of experience in chemical/pharmaceutical process development
Additional Skills and Preferences:
•
Experience with design, development, and optimization of synthetic process manufacturing unit operations.
•
Experience with modeling and simulation tools, data analytics and predictive analytics.
•
Experience in batch and continuous unit operations. Experience on technical considerations for equipment design and integration, process monitoring, integration of process analytical technologies (PAT) systems.
•
Excellent oral communication and documentation skills.
•
Demonstrate ability to effectively collaborate with multidisciplinary teams.
•
Demonstrate leadership behaviors with ability to accept challenges, seek opportunities to remove barriers, influence without authority, and lead in areas of uncertainty
•
Demonstrate exemplary teamwork/interpersonal skills
•
Demonstrate problem solving, attention to detail and result oriented behaviors in a fast-paced environment.
Additional Information
•
Travel: 0 to 10%
•
Position Local: Indianapolis, IN LTC- N
Legal
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
Benefits
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$129,000 - $209,000
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
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