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Amgen

Scientist - LC-MS/MS Bioanalytical

Salary$109k – $147k
LocationUS - California - Thousand Oaks
Work modeon-site
Typefull-time
DepartmentScientific
EquityIncluded
Company size10,000+ people
First seen2w ago
Last seen4d ago
Career Category
Scientific
Job Description
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Scientist LC-MS/MS Bioanalytical
What you will do
Let’s do this. Let’s change the world. In this vital role you will independently support the design, development, validation, and implementation of robust quantitative LC-MS/MS bioanalytical methods and experiments for small molecules and perform bioanalysis for discovery, GLP preclinical and regulated clinical studies.
The position is lab-based, and additional responsibilities will include critically reviewing and interpreting scientific data and results, report generation, project management, communication of results, data presentations, supporting automation efforts, and keeping current with technology development.
The role will involve multidisciplinary collaborations with scientists across research and development at Amgen and may include contribution to key/critical teams and participation in national scientific meetings. This position is also responsible for providing scientific results that may support the generation of publications, patents or regulatory submissions. Familiarity with peptide and protein quantitation by hybrid LC-MS/MS methodology and affinity capture techniques a plus.
Responsibilities
Key Responsibilities:
• Develop and implement LC-MS/MS bioanalytical methods with quick turnaround times. Conduct small molecule bioanalysis of parent and metabolites in non-clinical and clinical samples from various matrices (plasma, urine, CSF, tissues).
• Perform biological sample extraction using protein precipitation, SPE, and LLE.
• Generate complete, accurate, and concise documentation using LIMS and electronic laboratory notebook systems.
• Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines.
• Author study reports, standard operating procedures, analytical methods, memos, scientific publications, and other regulatory compliant documents.
• Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings.
• Comply with safety guidelines and site-specific procedures which include but are not limited to the completion of training on assigned tasks, maintenance of training records, laboratory documentation, and following detailed SOPs and other written procedures.
• Perform general laboratory housekeeping activities and operational support as needed.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a researcher with these qualifications.
Basic Qualifications:
Doctorate degree PhD
OR
PharmD
OR
MD [and relevant post-doc where applicable]
OR
Master’s degree and 3 years of LC-MS/MS Bioanalytical experience
OR
Bachelor’s degree and 5 years of LC-MS/MS Bioanalytical experience
Preferred Qualifications:
•
Prior experience in pharma/biotech strongly desired.
•
Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms.
•
Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, tissues, urine, cerebrospinal fluid) employing diverse sample preparation techniques (e.g., SPE, LLE) to support analysis of small molecules and metabolites by LC-MS/MS.
•
Experience with an array of analytical equipment and technologies that can accelerate bioanalysis including automation and/or micro-sampling.
•
Prior GLP and GCP experience.
•
Prior experience in bioanalytical (regulated) assay execution and method transfer to external contract laboratories.
•
Understanding of pharmacokinetic and toxicokinetic principles and analysis.
•
Must be willing to work in a fast-paced, multi-project environment with high workload demands, and consistently deliver high-quality results within established timelines.
•
Demonstrated ability to efficiently resolve scientific challenges, prioritize and effectively manage multiple projects.
•
Excellent scientific problem-solving skills.
•
Excellent project and time management abilities.
•
Ability to work collaboratively with internal and external stakeholders.
•
Supervisory and mentoring experience in a lab-based setting.
What you can expect from us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
•
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
•
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
•
Stock-based long-term incentives
•
Award-winning time-off plans
•
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.
careers.amgen.com
Legal
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Sponsorship
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
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Salary Range
109,020.15USD -147,497.85 USD
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