Senior/Principal Scientist, Computational Neuroscience, Computational Sciences Center of Excellence
Salary$145k – $299k
LocationSouth San Francisco
Work modehybrid
Typefull-time
SeniorityLead
Experience3+ yrs
DepartmentComputational Biology & Medicine
Company size10,000+ people
First seenOct 6, 2026 · 5d ago
Verified live1d ago
At a glanceSummarised by Seekless from the posting.
Must have11
PhD or equivalent with in-depth training in a relevant field
Deep understanding of both biological pathways relevant to neurodegeneration/neuroimmunology and computational methods to study these pathways
Successful postdoctoral research or ≥3 years equivalent experience after PhD (Principal Scientist)
Experience with Perturb-seq and related CRISPR screening
Experience with patient tissue or CSF/PBMC atlases
Use of human genetics to prioritize drug targets
Familiarity with AI approaches and AI agents to enable scientific insights
Track record of impactful scientific achievement demonstrated by co-first/lead as well as contributing author publications
Excellent communication skills
Evidence of success in complex, multidisciplinary environments
Onsite presence in South San Francisco at least 3 days a week
Skills
LLMs
AI agents
Python
R
CRISPR
single-cell RNA sequencing
human genetics
AI
Benefits
Health insurance
401(k)
Annual bonus
Relocation assistance
About the company
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.
Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness this transformative power of data and Artificial Intelligence (AI) to assist our scientists in delivering more innovative and transformative medicines for patients worldwide.
About the role
We seek a creative and highly accomplished scientist to develop and execute Genentech/Roche’s Foundational Data and Models strategy in Computational Neuroscience, helping to deliver new treatments for neurodegenerative and neuroinflammatory diseases such as Alzheimer’s, Parkinson’s, ALS and multiple sclerosis, in the department of Computational Biology & Medicine within the Roche Computational Sciences Center of Excellence (CS-CoE).
The Opportunity:
•
Working within and extending Roche’s existing data ecosystems to accelerate our Neuroscience portfolio.
•
Developing strategy to effectively mine large data and drive science using LLMs, advanced automation and AI agents.
•
Analysis and integration of human genetic, single-cell atlases, perturbation and other data types to derive novel insights into the pathobiology of neurodegenerative and neuroinflammatory diseases.
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Nomination of new entries to Neuroscience department Target Assessment Portfolio and identification of new biomarkers for existing therapeutic programs.
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Serving as computational lead on pipeline programs, supporting target validation, mechanism of action, safety and biomarker studies
Who You Are:
•
PhD or equivalent with in-depth training in a relevant field, and deep understanding of both biological pathways relevant to neurodegeneration/neuroimmunology and computational methods to study these pathways (Senior Scientist). Additionally, successful postdoctoral research or ≥3 years equivalent experience after PhD (Principal Scientist).
•
The ideal candidate will have deep experience in many of the following types of analysis:
•
Perturb-seq and related CRISPR screening
•
Patient tissue or CSF/PBMC atlases
•
Use of human genetics to prioritize drug targets
•
Familiarity with AI approaches and AI agents to enable scientific insights
•
A track record of impactful scientific achievement, which may be demonstrated by co-first/lead as well as contributing author publications
•
Excellent communication skills and evidence of success in complex, multidisciplinary environments
Onsite presence, on our South San Francisco campus, is expected for at least 3 days a week.
Benefits
Relocation benefits will be available for this posting.
The expected salary range for this position based on the primary location of South San Francisco, California is $144,900 - $269,100 (Senior Scientist) and $161,000 - $299,000 (Principal Scientist). Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
#ComputationCoE
Legal
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.