Scientist II, Cellular Neuroscience and Translational Pharmacology
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Before you apply
LocationNew York, New York
Also inNortheast and Mid-Atlantic
Work modeon-site
Typefull-time
SeniorityMid
Experience1–3 yrs
DepartmentPre-clinical
Company size7+ people
PostedOct 13, 2026 · 3w ago
Verified live2d ago
At a glanceSummarised by Seekless from the posting.
PhD in pharmacology, neuroscience, molecular biology, chemical biology, cell biology, or a related discipline
1 to 3 years of biotechnology or pharmaceutical industry experience
Demonstrated experience in cellular pharmacology, assay development, and iterative drug discovery or lead optimization
Hands-on experience with neuronal cell culture models, preferably human iPSC-derived neurons or glia
Expertise in concentration-response, time-course, target-engagement, pharmacodynamic, quantitative data-analysis, and troubleshooting studies
Concrete examples of scientific ownership in which an assay, platform, or data package influenced a program decision
Excellent communication skills and willingness to maintain a substantial hands-on laboratory presence
Enzyme biology, epigenetics, or transcriptional pharmacology; therapeutic proteins or targeted-delivery constructs; cellular uptake, trafficking, or protein quantification; mitochondrial functional assays; high-content imaging or neuronal functional assays; transferrin receptor biology, BBB transport, or biodistribution; laboratory start-up, assay transfer, or CRO management
Exposure to ASO screening or RNA pharmacology is beneficial
About the role
Role Summary
We are seeking a highly collaborative, hands-on Scientist II to help establish a preclinical neuroscience laboratory supporting small-molecule and protein therapeutics. The immediate priorities are rapid cellular profiling and lead selection for an advanced small-molecule enzyme program, and leadership of cellular development for a transferrin-based protein replacement project. The role will also build fit-for-purpose human neuronal models, laboratory workflows, and external partnerships.
Location
We welcome applications from candidates located across the Northeast and Mid-Atlantic.
Primary Responsibilities
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Lead a rapid, tiered cellular assay strategy for small-molecule lead optimization, including target engagement, pharmacodynamics, concentration-response, duration, selectivity, neuronal phenotype, stress, and tolerability
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Lead cellular development of a transferrin-based protein replacement project by establishing quantitative assays for construct uptake, internalization, intracellular trafficking, protein abundance and integrity, mitochondrial response, and disease-relevant phenotypic rescue
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Use orthogonal methods to distinguish surface-bound, internalized, degraded, and functionally delivered protein; compare constructs and define advancement criteria
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Establish fit-for-purpose neuronal culture models, including iPSC-derived neurons or glia where they add decision value, with appropriate banking and quality control
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Define assay controls, acceptance criteria, reproducibility standards, analysis plans, SOPs, sample tracking, and electronic documentation
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Translate data into concise recommendations to advance, modify, or discontinue assets
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Partner across protein engineering, chemistry, bioanalysis, DMPK, pathology, computational biology, and in vivo pharmacology; scientifically manage CROs and assay transfers
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Mentor junior scientists and build workflows that are reproducible across operators. Future scope may include ASO screening in partnership with external experts
Required Skills and Qualifications
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PhD in pharmacology, neuroscience, molecular biology, chemical biology, cell biology, or a related discipline, plus 1 to 3 years of biotechnology or pharmaceutical industry experience
•
Demonstrated experience in cellular pharmacology, assay development, and iterative drug discovery or lead optimization
•
Hands-on experience with neuronal cell culture models, preferably human iPSC-derived neurons or glia
•
Expertise in concentration-response, time-course, target-engagement, pharmacodynamic, quantitative data-analysis, and troubleshooting studies
•
Concrete examples of scientific ownership in which an assay, platform, or data package influenced a program decision
•
Excellent communication skills and willingness to maintain a substantial hands-on laboratory presence
Preferred Skills and Qualifications
•
Enzyme biology, epigenetics, or transcriptional pharmacology; therapeutic proteins or targeted-delivery constructs; cellular uptake, trafficking, or protein quantification; mitochondrial functional assays; high-content imaging or neuronal functional assays; transferrin receptor biology, BBB transport, or biodistribution; laboratory start-up, assay transfer, or CRO management
•
Exposure to ASO screening or RNA pharmacology is beneficial
About LEXEO
Lexeo Therapeutics is a New York City-based, clinical stage company dedicated to reshaping the path of genetic disease. By advancing pioneering science, Lexeo seeks to set a new standard in the treatment of cardiovascular and neurological genetic diseases, charting the path to patient outcomes once thought out of reach. The Company is advancing a portfolio of therapeutic candidates designed to address the underlying genetic causes of disease, including LX2006 for Friedreich ataxia (FA), LX2020 for plakophilin-2 (PKP2) arrhythmogenic cardiomyopathy, and others in devastating diseases with high unmet need.
LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.