Scientist/Senior Scientist in T-cell Engager (TCE) Development
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Before you apply
Salary$120k – $160k
Location2325 3rd St, Suite 328, San Francisco, CA
Work modeon-site
Typefull-time
SenioritySenior
Experience2+ yrs
DepartmentResearch and Development
EquityIncluded
Company size4+ people
PostedMay 11, 2026 · 6mo ago
Verified live18h ago
May no longer be actively hiring
Posted by the company on May 11, 202660% of this company's open roles have been listed for 90+ days
At a glanceSummarised by Seekless from the posting.
PhD degree in Biochemistry, Protein engineering, Bioengineering, or a related field.
Strong background in Biochemistry, Protein engineering, and Molecular biology.
2+ years of industry experience leading the design, production, and developability optimization of TCEs or multi-specific antibodies.
Ability to work in a fast-paced startup environment, take initiative, and drive projects forward independently.
Excellent communication and collaboration skills.
Experience with library construction/screening using phage/yeast display.
Experience with antibody purification using AKTA system.
Experience working with CROs.
Skills
AKTA
phage display
yeast display
Benefits
Health insurance
Dental insurance
Vision insurance
401(k)
Commuter benefits
Daily lunch
Life insurance
Disability insurance
About the company
We are a well-funded biotech company that is redefining biologics discovery and development through our fully integrated platform. We combine ultra-high-throughput microfluidics driven functional screening, computational engineering, and translational immunology into a unified engine. Rather than approaching biologics development as a series of disconnected steps, we seamlessly integrate the discovery of novel targets, functional screening of binders, computational optimization, and predictive safety assessment to develop more better and safer therapeutics. This end-to-end approach enables faster iteration, deeper biological insight, and the development of better TCEs with greater precision and confidence.
About the role
We are currently looking for a TCE development scientist to join our interdisciplinary team. The candidate is expected to adapt quickly and communicate well, especially in a fast-paced startup environment. They will collaborate with other team members and be part of an exciting journey. We pay competitive salaries with bonus and equity, plus full benefits that include medical, dental, vision, 401k match, commuter benefits and daily lunch.
Responsibilities:
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Design TCEs and execute their development and optimization campaigns.
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Work with internal and external teams on antibody discovery, TCE production and characterization.
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Drive TCE developability assessment and biophysical characterization.
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Manage external relationships and deliverables.
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Collaborate cross-functionally with computational scientists and immunologists to optimize and validate candidate molecules through iterative engineering and in vitro/in vivo studies.
Skills and Qualifications:
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PhD degree in Biochemistry, Protein engineering, Bioengineering, or a related field.
•
Strong background in Biochemistry, Protein engineering, and Molecular biology.
•
2+ years of industry experience leading the design, production, and developability optimization of TCEs or multi-specific antibodies.
•
Experience with library construction/screening using phage/yeast display is a plus.
•
Experience with antibody purification using AKTA system is a plus.
•
Experience working with CROs is plus.
•
Ability to work in a fast-paced startup environment, take initiative, and drive projects forward independently.
•
Excellent communication and collaboration skills.
Compensation and Benefits:
Compensation:
•
$120,000 - $160,000 (depending on the depth of expertise) + 4% 401K match + 10% performance bonus + equity.
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We will also consider a Principal Scientist with proven technical expertise plus cross-functional project leadership. Compensation will be adjusted accordingly.
Benefits:
•
Daily lunches; Commuter Benefits; Unlimited snacks and drinks.
•
Medical, Dental, Vision; 100% Premium Covered.
•
Disability Insurance, Life Insurance; Workplace Insurance
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