Senior Research Associate, Genome Sciences & Engineering
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Before you apply
Salary$100k – $110k
LocationStylus Medicine, Cambridge, Massachusetts, United States
Typefull-time
SenioritySenior
Experience1+ yrs
DepartmentGenome Engineering Platform
Company size11–50 people
PostedNov 6, 2026 · 1d ago
Verified live11h ago
At a glanceSummarised by Seekless from the posting.
BS with 3+ years or MS with 1+ years relevant experience
Experience conducting high-throughput cell-based screens
Proficiency with primary T cells, hepatocytes, and/or cancer cell lines
Hands-on experience with gene editing technologies (e.g. CRISPR nucleases, recombinases, base editors, or transcriptional effectors)
Familiarity with laboratory automation platforms for cell-based screening workflows
Familiarity with flow cytometry
Experience with nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
Track record of independently generating precise, reproducible data and performing rigorous quantitative analysis
Clear and approachable communication skills
Exceptional organizational skills and comfort managing complex datasets and overlapping projects
Strategic thinker who effectively plans and prioritizes
Collaborative mindset with a team-first attitude
Creative problem-solver who thrives amid scientific uncertainty
Working with LNPs preferred
Skills
LNPs
CRISPR
recombinases
base editors
transcriptional effectors
TapeStation
Qubit
NanoDrop
qPCR
flow cytometry
laboratory automation
About Stylus Medicine:
Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.
About the Role:
Stylus Medicine is seeking a Senior Research Associate to join our Genome Sciences & Engineering team. In this role, the Senior Research Associate will drive the execution of cell-based assays and high-throughput screening workflows to advance the company’s LSR-based genome editing platforms. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing.
Key Responsibilities & Accountabilities:
•
Execute cell-based assays and high-throughput (HT) screening workflows that advance platform and program objectives, working both independently and as part of a cross-functional team
•
Develop and execute arrayed and pooled HT screening campaigns with rigor and reproducibility
•
Troubleshoot experiments, analyze data, and translate results into actionable scientific insights
•
Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team
•
Partner cross-functionally to advance optimized candidates into translational and preclinical development
Qualifications & Skills:
•
BS with 3+ years or MS with 1+ years relevant experience in cell biology, molecular biology, or a related field
•
Experience conducting high-throughput cell-based screens; proficiency with primary T cells, hepatocytes, and/or cancer cell lines, working with LNPs preferred
•
Hands-on experience with gene editing technologies (e.g. CRISPR nucleases, recombinases, base editors, or transcriptional effectors)
•
Familiarity with laboratory automation platforms for cell-based screening workflows, flow cytometry
•
Experience with nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
•
Track record of independently generating precise, reproducible data and performing rigorous quantitative analysis
•
Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences
•
Exceptional organizational skills and comfort managing complex datasets and overlapping projects
•
Strategic thinker who effectively plans and prioritizes to maximize scientific impact
•
Collaborative mindset with a team-first attitude
•
Creative problem-solver who thrives amid scientific uncertainty
Pay Range: $100,000 - $110,000