At a glanceSummarised by Seekless from the posting.
Skills
cryo-EM
molecular docking
electrophysiology
patch-clamp
imaging techniques
CRISPR/cas9
biochemical methods
molecular approaches
Location
SAINT LOUIS, MO 63110
Scheduled Hours
40
Position Summary
The Sah laboratory at WashU Medicine in St. Louis (Department of Internal Medicine, Cardiology) and the Center for the Investigation of Membrane Excitability Disease (CIMED) studies the mechanisms of Transient Receptor Potential (TRP) and LRRC8a/ SWELL1 ion channel regulation and signal transduction. The laboratory uses electrophysiological (e.g., patch-clamp), imaging techniques, genetic mouse models (including CRISPR/cas9 technology), biochemical, and molecular approaches to investigate the regulation of signal transduction mechanisms of novel ion channels, including TRP/LRRC8 channels, in cardiac muscle, skeletal muscle, adipose tissue, and endothelium and pancreatic islet cells.
Broadly speaking, the overarching goal of the Sah laboratory is to understand how ion channels and mechano-signaling influence cellular and organismal metabolism. We also combine medicinal chemistry with cryo-EM structure, molecular docking, and functional studies to guide synthesis of novel ion channel modulators for the treatment of human disease.
Job Description
Primary Duties & Responsibilities:
Working Conditions:
A laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment, provide standard care to research animals, and handle human biosamples.