We are seeking a highly motivated and innovative scientist to join the New Approach Methodologies (NAMs)/Complex In Vitro Models (CIVMs) pillar within Lilly’s Investigative Toxicology group. This individual contributor, primarily laboratory-based role sits within an integrated group where in vitro and in vivo safety science are united under a single leadership, enabling seamless translational science across the drug discovery continuum.
The successful candidate will serve as the primary scientific contributor to Lilly’s CNS/PNS safety NAMs capability - designing, qualifying, and applying advanced human-relevant in vitro models to detect, characterize, and mechanistically understand compound-induced liabilities across the central nervous system (CNS), peripheral nervous system (PNS), and blood-brain barrier (BBB). Liabilities of primary interest include neurotoxicity (excitotoxicity, neuroinflammation, mitochondrial dysfunction), seizurogenic and network activity perturbation, demyelination, peripheral neuropathy/axonopathy, and BBB integrity disruption. The role demands scientific depth in neural biology, a mechanistic attitude toward safety translation, and the drive to advance neuronal CIVM science both internally and externally.