Postdoctoral Fellow - Structural Biology and Drug Discovery
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Before you apply
SalaryNo pay range posted
LocationUnited States-California-Duarte
Work modeon-site
SeniorityEntry
Company size10,000+ people
First seenOct 18, 2026 · 2w ago
Verified live1d ago
At a glanceSummarised by Seekless from the posting.
Ph.D. in life sciences, biomedical sciences, structural biology, biochemistry, or a related discipline
Prior experience in protein biochemistry and X-ray crystallography
Demonstrated record of successful research projects and publications
Excellent analytical and problem-solving skills
Strong communication and collaboration skills
Use X-ray crystallography to support structure-guided drug design, lead recombinant protein expression and purification, and conduct quantitative biophysical and biochemical binding studies, such as SPR, ITC, and DSF
Collaborate in a highly integrated research environment that brings together structural biology, chemical biology, and translational science
Familiarity with redox biology, inflammatory signaling, or fragment-based discovery approaches
About the company
Join the forefront of groundbreaking research at City of Hope, where we are changing lives and making a meaningful impact in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are united by a shared mission: to contribute to innovative approaches that predict, prevent, and cure disease while helping shape the future of medicine through cutting-edge research.
About the role
The Dr. Jeff Perry laboratory in the Beckman Research Institute of City of Hope is seeking a highly motivated Postdoctoral Fellow to join a multidisciplinary drug discovery program focused on a redox-sensitive regulatory protein at the intersection of cellular stress responses, inflammation, and metabolic disease, including diabetes. This project aims to develop first-in-class small-molecule modulators of a protein that links oxidative stress to inflammatory signaling pathways, with strong therapeutic potential in metabolic and inflammatory disorders.
As a successful candidate, you will:
•
Use X-ray crystallography to support structure-guided drug design, lead recombinant protein expression and purification, and conduct quantitative biophysical and biochemical binding studies, such as SPR, ITC, and DSF.
•
Collaborate in a highly integrated research environment that brings together structural biology, chemical biology, and translational science.
Your qualifications should include:
•
Ph.D. in life sciences, biomedical sciences, structural biology, biochemistry, or a related discipline is required.
•
Prior experience in protein biochemistry and X-ray crystallography is essential.
•
Familiarity with redox biology, inflammatory signaling, or fragment-based discovery approaches is advantageous.
•
Demonstrated record of successful research projects and publications.
•
Excellent analytical and problem-solving skills.
•
Strong communication and collaboration skills.
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
City of Hope is an equal opportunity employer.
Benefits
To learn more about our Comprehensive Benefits, pleaseCLICK HERE.