Postdoctoral Fellow - Structural Biology and Drug Discovery
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Before you apply
SalaryNo pay range posted
LocationUnited States-California-Duarte
Work modeon-site
Typefull-time
SeniorityEntry
Company size10,000+ people
First seenOct 18, 2026 · 2w ago
Verified live1d ago
At a glanceSummarised by Seekless from the posting.
Ph.D. in life sciences, biomedical sciences, or a related discipline is required.
Prior experience in protein biochemistry and X-ray crystallography is essential.
Proven track record of successful research projects and publications.
Excellent analytical and problem-solving skills.
Effective communication and collaboration abilities.
Experience in quantitative biophysical characterization of small-molecule binding studies such as SPR, ITC, and DSF and/or an interest in mechanism-driven drug discovery and fragment-based approaches is highly desirable.
Skills
X-ray crystallography
SPR
ITC
DSF
About the company
Join the forefront of groundbreaking research at City of Hope, where we are changing lives and making a meaningful impact in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are united by a shared mission: to contribute to innovative approaches that predict, prevent, and cure disease while helping shape the future of medicine through cutting-edge research.
About the role
The Dr. Jeff Perry laboratory in the Beckman Research Institute of City of Hope is seeking a highly motivated postdoctoral fellow to join a multidisciplinary drug discovery program focused on a metabolic enzyme that plays a central role in cholesterol homeostasis and bile acid synthesis, with direct implications for metabolic disease and cardiometabolic risk.
As a successful candidate, you will:
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Lead efforts in recombinant protein expression and purification, and structure determination using X-ray crystallography to enable structure-guided ligand design.
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Collaborate at the interface of structural biology, chemical biology, and translational therapeutics, contributing to the development of first-in-class modulators targeting a clinically relevant metabolic pathway.
Your qualifications should include:
•
Ph.D. in life sciences, biomedical sciences, or a related discipline is required.
•
Prior experience in protein biochemistry and X-ray crystallography is essential.
•
Experience in quantitative biophysical characterization of small-molecule binding studies such as SPR, ITC, and DSF and/or an interest in mechanism-driven drug discovery and fragment-based approaches is highly desirable.
•
Proven track record of successful research projects and publications.
•
Excellent analytical and problem-solving skills.
•
Effective communication and collaboration abilities.
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
City of Hope is an equal opportunity employer.
Benefits
To learn more about our Comprehensive Benefits, pleaseCLICK HERE.