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UBC

Postdoctoral Research Fellow – Human Neuroimmunology, Brain Organoids and Multi-omics

SalaryCA$65k – CA$75k
LocationUBC Vancouver Campus - Vancouver, BC, Canada
Work modeon-site
Typefull-time
SeniorityEntry
Experience5–10 yrs
DepartmentDepartment of Medicine | Faculty of Medicine (Jan Lunemann)
Company size10,000+ people
PostedAug 26, 2026 · 1mo ago
Verified live11m ago
At a glanceSummarised by Seekless from the posting.
Must have3
PhD (or equivalent) in neuroscience, immunology, stem cell biology, molecular biology, genetics, biomedical engineering, or a closely related discipline.
Ph.D. within 5 years or M.D./D.D.S. within 10 years
Demonstrated research excellence through peer-reviewed publications.
Nice to have19
Demonstrated ability to work independently and effectively in an interdisciplinary and collaborative research environment with excellent organizational and communication skills.
Commitment to enhancing awareness, knowledge and skills related to equity, diversity, and inclusion.
Scientific curiosity, creativity and a strong commitment to scientific rigor, reproducibility, and open science.
Experience working with human induced pluripotent stem cells (hiPSCs), human brain organoids, cerebral organoids, or neural assembloids and other three-dimensional CNS culture systems.
Strong background in cellular and molecular immunology, including human B-cell and T-cell biology, antibody responses, and humoral immunity, immune activation, immune regulation, and adaptive immune responses.
Knowledge of autoimmune and neuroinflammatory disease mechanisms.
Experience with complement biology or antibody-mediated neurological diseases is considered an asset.
Human immune cell isolation and culture.
Multicolour or spectral flow cytometry.
Functional immune assays, including T-cell activation, B-cell differentiation, cytokine profiling, ELISA, ELISpot, multiplex immunoassays, and immune-cell phenotyping and antibody characterization.
Experience with co-culture of immune cells with neural cells or organoids, human microglia differentiation and characterization, monocyte-derived macrophage culture and functional neuroimmune interaction assays.
Experience with CRISPR/Cas9 genome editing, CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa), generation of genetically engineered hiPSC lines, and viral vector technologies.
Experience with confocal microscopy, high-content imaging, live-cell imaging.
Three-dimensional image reconstruction and quantitative image analysis using Fiji/ImageJ, CellProfiler, Imaris, or related software.
Experience with single-cell RNA sequencing, single-cell multi-omics, spatial transcriptomics, proteomics, epigenomics, and immune repertoire sequencing.
Experience analysing high-dimensional biological datasets.
Proficiency in R for statistical analysis, visualization, and reproducible data analysis.
Experience with packages such as Seurat, Bioconductor, tidyverse, SingleCellExperiment, or related software.
Experience with Python and machine learning approaches is considered an asset.
Skills
human induced pluripotent stem cell (hiPSC) technology
brain organoids
genome engineering
advanced imaging
systems immunology
multi-omics
CRISPR/Cas-based genome engineering
confocal microscopy
live-cell imaging
high-content imaging
3D image analysis
single-cell RNA sequencing
spatial transcriptomics
proteomics
immune repertoire sequencing
bioinformatics
artificial intelligence
spectral flow cytometry
Fiji/ImageJ
CellProfiler
Imaris
Seurat
Bioconductor
tidyverse
SingleCellExperiment
R
Python
ELISA
ELISpot
multiplex immunoassays
CRISPRi
CRISPRa
viral vector technologies
Academic
Job Category
Faculty Non Bargaining
Job Title
Postdoctoral Research Fellow – Human Neuroimmunology, Brain Organoids and Multi-omics
Department
MS Research Network | Department of Medicine | Faculty of Medicine (Jan Lunemann)
Posting End Date
September 26, 2026
Legal
Note: Applications will be accepted until 11:59 PM on the Posting End Date.
Job End Date
September 30, 2028
Please note: This is a 2-year term appointment with the possibility of extension
Benefits
The expected pay range for this position is CAD $65,000–75,000 per annum plus benefits. The Department of Medicine, Faculty of Medicine is committed to offering equitable and competitive salaries, commensurate with the qualifications and experience of the candidate.
At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career.
Job Summary
The Laboratory of Professor Jan D. Lünemann, UBC Chair in Multiple Sclerosis and Autoimmune Neurology Research, invites applications for a highly motivated and intellectually curious Postdoctoral Fellow to join an interdisciplinary research program at the Djavad Mowafaghian Centre for Brain Health (DMCBH), one of Canada’s leading neuroscience research centres.
The successful candidate will develop next-generation human experimental models to investigate the cellular and molecular mechanisms underlying autoimmune and inflammatory diseases of the central nervous system, including multiple sclerosis, neuromyelitis optica spectrum disorders (NMOSD), MOG antibody-associated disease (MOGAD), autoimmune encephalitis, and related neurological disorders.
The project combines human induced pluripotent stem cell (hiPSC) technology, brain organoids, genome engineering, advanced imaging, systems immunology, and high-throughput multi-omics to investigate neuroimmune interactions and identify novel therapeutic targets.
The successful candidate will join a rapidly expanding international research program dedicated to uncovering the mechanisms of immune-mediated diseases of the nervous system through human discovery science. Embedded within an extensive interdisciplinary network of experts in neuroimmunology, stem cell biology, biomedical engineering, computational biology, artificial intelligence, and precision medicine across UBC, they will have access to cutting-edge research infrastructure, including human stem cell and organoid platforms, genome engineering technologies, advanced microscopy, spectral flow cytometry, single-cell and spatial genomics, proteomics and biomarker laboratories, and high-performance computational resources. The laboratory is deeply committed to excellent mentorship and fostering the professional development of early-career researchers through extensive national and international collaborations.
Organizational Status
The Postdoctoral Research Fellow will report directly to Professor Lünemann and collaborate closely with investigators across the Faculty of Medicine, DMCBH, the School of Biomedical Engineering, the Life Sciences Institute, and national and international collaborators.
Professor Lünemann is the inaugural UBC Chair in Multiple Sclerosis and Autoimmune Neurology Research and Director of the UBC MS & Neuromyelitis Optica Program. His laboratory combines human discovery science with advanced experimental technologies to understand disease mechanisms and develop precision therapeutics for autoimmune neurological diseases.
Work Performed
The successful candidate will:
•
Design and lead innovative research projects investigating mechanisms of neuroinflammation and neurodegeneration.
•
Generate and characterize human brain organoids and neural assembloids derived from human induced pluripotent stem cells (hiPSCs).
•
Differentiate hiPSCs into neural cell populations including neurons, astrocytes, oligodendrocytes, and microglia.
•
Develop complex neuroimmune co-culture systems incorporating immune cells into human CNS models.
•
Apply CRISPR/Cas-based genome engineering technologies to investigate disease-associated genes and signaling pathways.
•
Perform functional immunological experiments investigating immune-cell activation, cytokine responses, antibody-mediated mechanisms, complement activation, and neuroimmune communication.
•
Apply advanced microscopy techniques including confocal microscopy, live-cell imaging, high-content imaging, and three-dimensional image analysis.
•
Perform and integrate high-dimensional molecular analyses, including single-cell RNA sequencing, spatial transcriptomics, proteomics, immune repertoire sequencing, and other multi-omics technologies.
•
Collaborate with computational scientists to analyse large-scale datasets using state-of-the-art bioinformatics and artificial intelligence approaches.
•
Prepare manuscripts for publication in leading international journals.
•
Present research findings at national and international scientific meetings.
•
Contribute to grant applications and collaborative research initiatives.
•
Mentor graduate students, undergraduate trainees, and research assistants within the laboratory.
•
Contribute to establishing a collaborative, inclusive, and scientifically stimulating research environment.
Supervision Received
The candidate will work under the direct supervision of Professor Jan D. Lünemann while maintaining a high degree of scientific independence. The candidate will be expected to develop independent research directions aligned with the laboratory’s overall research strategy and contribute intellectually to collaborative projects.
Supervision Given
The candidate will provide scientific mentorship to graduate students, undergraduate researchers, visiting trainees, and research assistants, including technical training and day-to-day guidance within research projects.
Minimum Qualifications
•
PhD (or equivalent) in neuroscience, immunology, stem cell biology, molecular biology, genetics, biomedical engineering, or a closely related discipline.
•
Ph.D. within 5 years or M.D./D.D.S. within 10 years
•
Demonstrated research excellence through peer-reviewed publications.
Preferred Qualifications
•
Demonstrated ability to work independently and effectively in an interdisciplinary and collaborative research environment with excellent organizational and communication skills.
•
Commitment to enhancing awareness, knowledge and skills related to equity, diversity, and inclusion.
•
Scientific curiosity, creativity and a strong commitment to scientific rigor, reproducibility, and open science.
Stem Cell Biology and Disease Modelling
•
Experience working with human induced pluripotent stem cells (hiPSCs),human brain organoids, cerebral organoids, or neural assembloids and otherthree-dimensional CNS culture systems.
Neuroimmunology and Immunology
•
Strong background in cellular and molecular immunology, including human B-cell and T-cell biology, antibody responses, and humoral immunity, immune activation, immune regulation, and adaptive immune responses.
•
Knowledge of autoimmune and neuroinflammatory disease mechanisms.
•
Experience with complement biology or antibody-mediated neurological diseases is considered an asset.
Immunological Techniques
•
Human immune cell isolation and culture.
•
Multicolour or spectral flow cytometry.
•
Functional immune assays, including T-cell activation, B-cell differentiation, cytokine profiling, ELISA, ELISpot, multiplex immunoassays, and immune-cell phenotyping andantibody characterization
Neuroimmune Co-culture Competency
•
Experience with co-culture of immune cells with neural cells or organoids, human microglia differentiation and characterization, monocyte-derived macrophage culture and functional neuroimmune interaction assays.
Genetic Engineering
•
Experience with CRISPR/Cas9 genome editing, CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa), generation of genetically engineered hiPSC lines, and viral vector technologies.
Advanced Imaging
•
Experience with ocnfocal microscopy, high-content imaging,live-cell imaging.
•
Three-dimensional image reconstruction and quantitative image analysis using Fiji/ImageJ, CellProfiler, Imaris, or related software.
High-throughput Multi-omics
•
Experience with single-cell RNA sequencing, single-cell multi-omics,spatial transcriptomics, proteomicsepigenomics, and
•
immune repertoire sequencing.
Bioinformatics and Data Analysis
•
Experience analysing high-dimensional biological datasets.
•
Proficiency in R for statistical analysis, visualization, and reproducible data analysis.
•
Experience with packages such as Seurat, Bioconductor, tidyverse, SingleCellExperiment, or related software.
•
Experience with Python and machine learning approaches is considered an asset.
APPLICATION PROCEDURE
Applicants should submit:
•
Cover letter
•
Curriculum vitae
•
Research statement (1–2 pages)
•
Contact information for three references
•
Up to three representative publications
We invite interested candidates to submit an application via Workday. Applications will be reviewed on an ongoing basis and continue until the position is filled. The anticipated start date for this position is November 2, 2026 or on a mutually agreed upon date. Should you have any queries around this position, please contact Dr. Jan Lünemann at [email protected].
The University of British Columbia is committed to creating and maintaining an inclusive, equitable, and diverse workplace. We welcome applications from all qualified candidates and encourage applications from members of groups that have been historically, persistently, or systemically underrepresented in academia. An inclusive work environment presumes an environment where differences are appreciated, recognized, and integrated into current structures, planning, and decision-making modes. Within this hiring process we are committed to creating an inclusive and equitable process for all candidates (including but not limited to people with disabilities). Confidential accommodations are available on request. Please contact Sabina Riar , Assistant HR Manager via email at [email protected]. If you have any questions regarding accommodations or accessibility during the recruitment and hiring process or for more information and support, please visit UBC’s Centre for Workplace Accessibility website at https://hr.ubc.ca/health-and-wellbeing/workplace-accessibility/centre-workplace-accessibility or contact the Centre at [email protected].
About the company
The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world. Since 1915, UBC’s entrepreneurial spirit has embraced innovation and challenged the status quo. UBC encourages its students, staff and faculty to challenge convention, lead discovery and explore new ways of learning. At UBC, bold thinking is given a place to develop into ideas that can change the world.
Our Vision: To Transform Health for Everyone
Ranked among the world’s top medical schools with the fifth-largest MD enrollment in North America, the UBC Faculty of Medicine is a leader in both the science and the practice of medicine. Across British Columbia, more than 12,000 faculty and staff are training the next generation of doctors and health care professionals, making remarkable discoveries, and helping to create the pathways to better health for our communities at home and around the world.
The Faculty of Medicine —comprised of approximately 2,600 administrative support, technical/research and management and professional staff, as well approximately 620 full-time academic and over 14,000 clinical faculty members—is composed of 19 academic basic science and/or clinical departments, 3 schools, and 26 research centres and institutes. Together with its University and Health Authority partners, the Faculty of Medicine delivers innovative programs and conducts research in the areas of health and life sciences. Faculty, staff and trainees are located at university campuses, clinical academic campuses in hospital settings and other regionally based centres across the province.
The UBC Vancouver Campus is located on the traditional, ancestral, and unceded territory of the xʷməθkʷəy̓əm (Musqueam) people. The City of Vancouver is located on Musqueam, Squamish, and Tsleil-Waututh First Nations territory.
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