Principal Scientist/Senior Scientist, Cryo-EM Structural Biology
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Before you apply
SalaryCHF 94k – CHF 174k
LocationBasel (City)
Work modeon-site
Typefull-time
SeniorityLead
Experience5+ yrs
Company size10,000+ people
PostedNov 3, 2026 · 5d ago
Verified live1d ago
At a glanceSummarised by Seekless from the posting.
PhD in a relevant scientific discipline with at least five years of research experience, or an equivalent combination of training and experience
Deep expertise in Cryo-EM, including sample preparation, single-particle analysis, structure determination, model building, and structural interpretation
Hands-on experience operating high-end cryo-transmission electron microscopes
Demonstrated experience in the expression and purification of a range of protein targets
Excellent written and spoken English, with strong scientific communication and presentation skills
Strong analytical skills, attention to detail, and a collaborative approach to working within multidisciplinary scientific teams
Experience troubleshooting and optimizing experimental and data-processing workflows for single-particle analysis and cryo-electron tomography
Familiarity with artificial intelligence-based and computational tools for protein construct design and optimization
Experience characterizing protein-ligand interactions
Hands-on experience with single-particle analysis, cryo-electron tomography, and dual-beam scanning electron microscopy
Skills
Cryo-EM
cryo-transmission electron microscopes
Nuclear Magnetic Resonance spectroscopy
X-ray crystallography
Cryo-Electron Microscopy
Salary Range:
CHF93,800.00 - CHF174,200.00
Job Description Summary
Role Type: Onsite Working,
Location: Basel, Switzerland
Relocation Support: This role is based in Basel, Switzerland. Novartis is unable to offer relocation support: please only apply if accessible.
What if your expertise in structural biology could reveal the molecular insights that unlock the next generation of medicines? As Principal Scientist/Senior Scientist, Cryogenic Electron Microscopy (Cryo-EM) Structural Biology, you will join the Protein Sciences group within Discovery Sciences, applying cutting-edge Cryo-EM to challenging targets across early drug discovery. Working with scientists across Biomedical Research, you will prepare biological samples, generate and interpret high-quality structural data, and translate molecular insights into actionable science that supports the discovery of novel therapeutic candidates.
Job Description
Key Responsibilities:
•
Contribute experimentally and scientifically to early drug-discovery projects within multidisciplinary teams.
•
Prepare biological samples for Cryo-EM, including data collection, processing, structural determination, and model building.
•
Apply current Cryo-EM technologies and methodologies to generate high-quality structural insights for drug discovery.
•
Collaborate closely with laboratory associates, providing mentoring and technical training within a matrix environment.
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Maintain accurate experimental records, scientific documentation, and instrument logs to support data quality and reproducibility.
•
Communicate structural biology findings through internal and external presentations and scientific publications.
Essential Requirements:
•
PhD in a relevant scientific discipline with at least five years of research experience, or an equivalent combination of training and experience.
•
Deep expertise in Cryo-EM, including sample preparation, single-particle analysis, structure determination, model building, and structural interpretation.
•
Hands-on experience operating high-end cryo-transmission electron microscopes.
•
Demonstrated experience in the expression and purification of a range of protein targets.
•
Excellent written and spoken English, with strong scientific communication and presentation skills.
•
Strong analytical skills, attention to detail, and a collaborative approach to working within multidisciplinary scientific teams.
Desirable Requirements:
•
Experience troubleshooting and optimizing experimental and data-processing workflows for single-particle analysis and cryo-electron tomography.
•
Familiarity with artificial intelligence-based and computational tools for protein construct design and optimization.
•
Experience characterizing protein-ligand interactions.
•
Hands-on experience with single-particle analysis, cryo-electron tomography, and dual-beam scanning electron microscopy.
Why Novartis:
At Novartis, you will join a collaborative Protein Sciences team applying complementary technologies, including biophysics, Nuclear Magnetic Resonance spectroscopy, X-ray crystallography, and Cryo-Electron Microscopy, to advance target-based drug discovery and novel therapeutic candidates.
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