Principal Scientist I/II —CAR-T Lead
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Before you apply
SalaryNo pay range posted
LocationCambridge (USA)
Work modeon-site
Typefull-time
SeniorityLead
Experience1–2 yrs
DepartmentOncology Immune Therapeutics
Company size10,000+ people
PostedOct 30, 2026 · 1w ago
Verified live1d ago
At a glanceSummarised by Seekless from the posting.
PhD scientist with 1-2 years of relevant experience
Expertise in CAR-T engineering and T-cell biology
Design, generate, and evaluate CAR constructs
Skills
CAR-T engineering
lentiviral constructs
Job Description Summary
Location: Cambridge, MA, USA
We are seeking a highly motivated PhD scientist with 1–2 years of relevant experience to join a multidisciplinary cell therapeutics discovery team within Oncology Immune Therapeutics and contribute to pioneering CAR-T cell therapies. As a key individual contributor, the successful candidate will work closely with cross-functional research partners, applying expertise in CAR-T engineering and T-cell biology to investigate novel cell therapy platforms and design, generate, and evaluate CAR constructs. The candidate will generate high-quality data that deepens our understanding of emerging CAR-T therapies, informs research and development decisions, and contributes to the design of future clinical trials. This position is ideal for a talented, results-oriented scientist who wishes to combine an interest in cancer immunobiology with a strong desire to discover and develop innovative cellular therapeutic approaches.
Job Description
Key Responsibilities
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Design and execute innovative research to advance next-generation CAR-T approaches, translating project objectives into experimental plans and decision criteria.
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Design, generate, and evaluate complex lentiviral constructs for logic-gated CAR-T approaches.
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Perform hands-on functional testing and optimization of CAR-T cells, and collaboratively develop and test novel analytical methods.
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Execute cell-line engineering to develop fit-for-purpose experimental models to evaluate function and inform construct selection.
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Critically analyze and integrate findings across engineering, in vitro biology, and in vivo pharmacology to inform candidate prioritization and translational opportunities.
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Collaboratively drive projects to meet established timelines while maintaining the highest quality and data integrity standards.
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Comply with established protocols and SOPs while performing experiments, and record and maintain meticulous records in an electronic laboratory notebook.
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Contribute to drafting technical documents and, where relevant to the program, scientific content for regulatory submissions.
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Present results, project updates, and recommendations to cross-functional teams, department meetings, and scientific leadership.
Essential Requirements
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